Psilocybin: The Next Big Thing In Treating Depression

Psilocybin, a psychoactive substance, has been shown to help people suffering from depression. It shows that psilocybin promotes openness and joy, which improves mood and behaviour. Psilocybin has also alleviated anxiety and depression symptoms by reducing the pervasive negative thought patterns associated with these conditions.

What is Psilocybin?

Psilocybin, a psychoactive substance, has been shown to help people suffering from depression. It shows that psilocybin promotes openness and joy, which improves mood and behaviour. Psilocybin has also alleviated symptoms of mental conditions by reducing the pervasive negative thought patterns associated with these conditions.

The most common hallucinogenic substances found in magic mushrooms are psilocybin and psilocin. However, the potency of these substances varies significantly across different species. Common psilocybin-containing mushroom species include Psilocybe cubensis, Psilocybe subaeruginosa, Psilocybe Mexicana, Psilocybe baeocystis, Psilocybe bohemica, and Psilocybe semilanceata.


Psilocybin-containing mushrooms are often tiny and brown or tan. People sometimes confuse psilocybin-containing mushrooms in the wild with various other dangerous fungi.

Psilocybin is typically consumed as brewed tea or combined with food to lessen its bitter taste. Additionally, producers manufacture dried mushrooms in capsule form by powdering them. These mushrooms are sometimes covered in chocolate by those who eat them.

How Psilocybin Works

Psilocybin changes the amount of serotonin in the brain. It is a well-known brain chemical that sends messages. It alters the level of serotonin in the brain by acting on the serotonin 1A receptor. The chemical reactions that cause the psychedelic effects release hormones and neurotransmitters. Psilocybin necessitates some procedures, such as disposal, digestion, and movement. It involves several processes, including elimination, digestion, and motility.

Understanding the molecular makeup of serotonin receptors makes it easier to understand how psilocybin works. The G-protein-coupled receptors include the brain surface serotonin receptors (GPCR).

When serotonin binds to specific receptors, the flow of ions into and out of the cell and across the cell membrane changes, serotonin changes how active a cell is and could stop it from firing too much or not enough.

Psilocybin Effects

Usually, psilocybin is ingested or smoked. Naturally, 4 to 8 hours after ingestion, its effects are felt. The results of psilocybin last for two hours and start to kick in 20 to 30 minutes after delivery. Psilocybin has the following primary outcomes:


Euphoria is typically understood in the 21st century as a very happy, content, and exciting feeling that can either be natural or inappropriate when connected to psychoactive drugs, manic episodes, or brain disorders or injuries. The characteristic effect of psilocybin is euphoria. Psilocybin exhibits result comparable to MDMA.

Sensory Effects

Psilocybin reduced the claustrum-auditory cortex connection. A strong psychedelic dose consistently influences sensory perception, including the sensation of being in a dream-like or imaginal state.

It was discovered that both visual and auditory senses are more pronounced. Colours can appear brighter, music can be more vital or distinct, and moving objects can move or dance.

Changes in Perception of Time

Psilocybin significantly reduced the capacity of participants to synchronize to inter-beat intervals longer than 2 seconds, reproduce interval durations longer than 2.5 seconds, and tap at their preferred rate.

Time may appear to increase or decrease. Changes might heighten awareness of the present moment or allow for introspective reflection.

Sense of Spiritual or Mystical Connection 

The peculiar states of consciousness known as mystical experiences are those in which a person learns that they are part of a continuous process with God, the universe, the Ground of Being, or whatever name he may choose due to cultural conditioning or personal preference for the ultimate and eternal reality.

Mood Changes

Reduced negative mood, enhanced good mood, and decreased amygdala sensitivity to negative affective stimuli are all acute psilocybin effects. In an emotional go/no-go paradigm, psilocybin causes a bias towards positive emotions and interferes with the perception of negative facial expressions.

How Does Psilocybin Work to Treat Depression?

Even though no one truly knows how psilocybin works, it is likely to work in the same way as other psychedelics like LSD and DMT. Psilocybin appears to have an impact on the prefrontal cortex and anterior cingulate cortex, two brain regions involved in the control of anxiety and depression, according to imaging studies. Most antidepressants, including SSRIs and tricyclics, focus on these brain areas. Psilocybin Canada and ketamine, a fast-acting antidepressant and anesthetic, have comparable effects.

Clinical Trials for Psilocybin

Two oral doses of psilocybin were administered to twelve patients (six men and six women) with moderate-to-severe unipolar major depressive disorder (10 mg and 25 mg, seven days apart) in a supportive environment as part of this open-label feasibility research. No control group existed. 

Before, during, and after each session, psychological support was provided. The primary indicator of feasibility was the intensity of the psilocybin effect reported by patients. We monitored patients for adverse reactions throughout the dosing sessions and subsequent clinic and remote follow-up.


Psilocybin not only generates significant and immediate effects but also has a lengthy duration, suggesting that it may be a beneficial treatment for depression. Unlike conventional antidepressants, which must take extended periods, psilocybin can relieve depressive symptoms with just one or two doses. More investigation is necessary to determine whether psilocybin is a helpful antidepressant. 




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